Bioengineers develop durable wearable diabetes monitoring device

June 26, 2017

esearchers at The University of Texas in the US believe they have created the first wearable diabetes monitoring device that can last up to a week, going beyond the single-use monitors available in the market today. Their durable device can also detect three diabetes-related compounds in microscopic amounts of perspiration.

Dr. Shalini Prasad, professor of bioengineering in the Erik Jonsson School of Engineering and Computer Science, and lead author Dr. Rujute Munje, a recent bioengineering PhD graduate, describe their wearable diagnostic biosensor that can detect three interconnected compounds — cortisol, glucose and interleukin-6 — in perspired sweat for up to a week without loss of signal integrity.

“If a person has chronic stress, their cortisol levels increase, and their resulting insulin resistance will gradually drive their glucose levels out of the normal range,” said Prasad, Cecil H. and Ida Green Professor in Systems Biology Science. “At that point, one could become pre-diabetic, which can progress to type 2 diabetes, and so on. If that happens, your body is under a state of inflammation, and this inflammatory marker, interleukin-6, will indicate that your organs are starting to be affected.”

Last October, Prasad and her research team confirmed they could measure glucose and cortisol in sweat. Several significant advances since then have allowed them to create a more practical, versatile tool.

“We wanted to make a product more useful than something disposable after a single use,” Prasad said. “It also has to require only your ambient sweat, not a huge amount. And it’s not enough to detect just one thing. Measuring multiple molecules in a combinatorial manner and tracking them over time allows us to tell a story about your health.”

One factor that facilitated their device’s progress was the use of room temperature ionic liquid (RTIL), a gel that serves to stabilize the microenvironment at the skin-cell surface so that a week’s worth of hourly readings can be taken without the performance degrading over time.

“This greatly influences the cost model for the device — you’re buying four monitors per month instead of 30; you’re looking at a year’s supply of only about 50,” Prasad said. “The RTIL also allows the detector to interface well with different skin types — the texture and quality of pediatric skin versus geriatric skin have created difficulties in prior models. The RTIL’s ionic characteristics make it somewhat like applying moisturizer to skin.”

Prasad’s team also determined that their biomarker measurements are reliable with a tiny amount of sweat — just 1 to 3 microliters, much less than the 25 to 50 previously believed necessary.

“We actually spent three years producing that evidence,” Prasad said. “At those low volumes, the biomolecules expressed are meaningful. We can do these three measurements in a continuous manner with that little sweat.”

Prasad envisions that her wearable devices will contain a small transceiver to send data to an application installed on a cellphone.

“With the app we’re creating, you’ll simply push a button to request information from the device,” Prasad said. “If you measure levels every hour on the hour for a full week, that provides 168 hours’ worth of data on your health as it changes.”

That frequency of measurement could produce an unprecedented picture of how the body responds to dietary decisions, lifestyle activities and treatment.

“People can take more control and improve their own self-care,” Prasad said. “A user could learn which unhealthy decisions are more forgiven by their body than others.”

Prasad has emphasized “frugal innovation” throughout the development process, making sure the end product is accessible for as many people as possible.

“We’ve designed this product so that it can be manufactured using standard coating techniques. We made sure we used processes that will allow for mass production without adding cost,” Prasad said. “Our cost of manufacturing will be comparable to what it currently takes to make single-use glucose test strips — as little as 10 to 15 cents. It needs to reach people beyond America and Europe — and even within first-world nations, we see the link between diabetes and wealth. It can’t simply be a small percentage of people who can afford this.”

For Prasad, the latest work is a fulfilling leap forward in what has already been a five-year process.

“We’ve been solving this problem since 2012, in three phases,” Prasad said. “The initial concept for a system level integration of these sensors was done in collaboration with EnLiSense LLC, a startup focused on enabling lifestyle based sensors and devices. In the market, there’s nothing that is a slap-on wearable that uses perspired sweat for diagnostics. And I think we are the closest. If we find the right partner, then within a 12-month window, we hope to license our technology and have our first products in the market.”

The researchers collaborated with EnLiSense LLC, a startup focused on enabling lifestyle based sensors and devices, for the initial concept of a system level integration of the sensors. According to Prasad, their sensor is the closest thing to a slap-on wearable that utilizes perspired sweat for diagnostics. She added that they hope to license the technology and have the first products in the market within a 12-month window if they find the right partner.

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