New imaging method could lead to earlier heart disease diagnosis, treatment

July 14, 2017

About 750,000 Americans have a heart attack every year. By the time someone knows he or she has blocked arteries, it’s too late to do much more than bypass surgery or putting in a stent to prop open the narrowed vessels. Sometimes a heart attack or stroke is the very first symptom.

But a new imaging method has been developed by Dr. Charalambos Antoniades of Britain’s University of Oxford and colleagues that could prove to be a better way of scanning someone’s heart to predict who is most at risk of a heart attack or stroke long before conventional imaging methods can do it.

The new imaging method detects inflamed fat cells as they are transforming into the inflamed, hardened plaques that clog up arteries.

The new method allows detector of small but inflamed artherosclerotic plaques in the heart arteries that are prone to rupture and are therefore about to cause a heart attack, Dr. Antoniades told reporters in a telephone briefing.

If the method holds up, doctors could start patients on drugs such as statins far earlier than they do now — in time to save them from ever developing serious heart disease, the researchers report.

It’s not just the fat cells that lead to heart disease, the No. 1 cause of death in the United State. It’s inflammation, also.

“Treatments that are known to reduce the risk of heart attacks, such as statin drugs, reduce inflammation much more than any detectable reduction in coronary artery narrowing,” said Oxford’s Keith Channon, who also worked on the study.

“But until now, there’s been no way to detect inflammation in the coronary arteries.

Doctors run many different tests to assess someone’s risk of heart disease. They measure cholesterol, blood pressure and heart rate, they test the electrical signals that keep the heart beating and they may also run imaging tests to check for clogged arteries.

But by the time a narrowed artery shows up on a standard scan, “it’s likely to be already too late to intervene and reverse the narrowing in the artery that has already occurred over many years,” Channon said.

“By detecting those individuals who don’t have narrowing in their heart arteries, but they are in the process in developing them because the arteries are inflamed, we may be able to intervene early enough to prevent heart disease.”

That’s why surgeons do heart bypasses. They graft in a vein to bypass blood flow around the clogged part.

The team studied more than 450 people having heart bypass surgery, removing some of the fat clogging their arteries. They compared them to 270 more having angiograms to look for evidence of clogged arteries.

They found a way to identify which layers of fat were inflamed and unstable by looking at the size and shape of the cells using computed tomography (CT) scans.

Dr. Antoniades said they are now further validating their method in larger numbers of patients in large prospective clinical studies to document and confirm the predictive value of the method for future heart attacks.


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