Faecal transplant used to treat inflammatory bowel disease in mice

June 6, 2022
Faecal transplant used to treat inflammatory bowel disease in mice

Changes in the composition of gut microbes is responsible for inflammation of the intestines in inflammatory bowel disease (IBD), said scientists from the Netherlands and the US – which can apparently be overcome through faecal transplants. Led by microbiologist Dr. Sahar El Aidy from the University of Groningen in the Netherlands, a team of scientists found changes of the gut microbial composition caused by the absence of the antimicrobial compound catestatin in mice with IBD.

In normal mice, catestatin is secreted by cells lining the gut and kills susceptible bacterial strains.

The scientists used faecal transplants in a group of mice genetically engineered to lack catestatin (knock-out mice) and in a group of normal mice, in order to find the cause of inflammation typical of IBD. Both groups of mice were given a laxative that removed most of the bacteria from their intestines instead of antibiotics, which could hamper recolonisation after the faecal transplant.

The results revealed that the microbial composition in the intestines had shifted towards that of the donor, indicating successful faecal transplants. Further, analysis of the metabolites inside the gut showed that the production of short-chain fatty acids, molecules that affect the function of the gut, was reduced in the knock-out mice.

“The reduction in short-chain fatty acid production was the result of a change in the microbial community in the intestines, which was in turn caused by the absence of catestatin,” explained Dr. El Aidy. “Our experiments showed that the epithelial permeability of the intestines, which is higher in the knock-out mice, is restored by the faecal transplant. Also, the extent of fibrosis resulting from inflammation was reduced.”

However, the scientists do not plan to treat human patients with faecal transplants because of contradictory outcomes.

Instead, the results from the new study have given the scientists a clear target to specific bacterial strains that are affected by the removal of catestatin, a school of thought which was missing in previous attempts to restore a healthy intestinal microbial community

Health Care Asia Home Faecal transplant used to treat inflammatory bowel disease in mice- Health Care Asia

Faecal transplant used to treat inflammatory bowel disease in mice

Tags:

Category: Community, Features

Comments are closed.

Subscribe to HCA for exclusive updates

Top Viewed News

12 simple steps to a healthy lifestyle

12 simple steps to a healthy lifestyle

Now that the world has returned to normalcy following the pandemic, everyone is back to their daily routines and encounters with stress... Read More

AZBIL: Envisioning the Future of Hospitals

AZBIL: Envisioning the Future of Hospitals

As we strive to be the hospital of choice, why not refine our commitment to excellence beyond the pivotal mission of saving lives?... Read More

Study Unlocks Key Findings on Asian Carriers of Breast Cancer

Study Unlocks Key Findings on Asian Carriers of Breast Cancer

Malaysian researchers at Cancer Research Malaysia (CRMY) and the University of Nottingham Malaysia (UNM) have published... Read More

 Unmasking the Risks of Mercury-Laden Cosmetics

Unmasking the Risks of Mercury-Laden Cosmetics

As the saying goes, beauty is in the eye of the beholder and thus subjective; but in some countries, the ideal of beauty begins... Read More

5 key hospital etiquettes to be mindful of when visiting a sick patient

5 key hospital etiquettes to be mindful of when visiting a sick patient

In moments of illness, the presence of loved ones can comfort and support. However, it’s important for visitors... Read More

Free counters!

2025 – 2026 Exhibitions



2025 Events


9-11 July
Medical Device Development (MEDIX) – Osaka
Makuhari Messe, Japan
www.manufacturing-world.jp


14-16 July
Lab Asia
Kuala Lumpur Convention Centre (KLCC), Malaysia
www.lab-asia.com


16-18 July
Medlab Asia | Asia Health
Malaysia International Trade & Exhibition Centre, Kuala Lumpur
www.medlabasia.com


24 July
Medlab Asia | Asia Health
Singapore
www.conversationaltechsummitasia.com


13-15 August
Philippines Medical
SMX Convention Center Manila Philippines
www.philmedical.com


21-23 August
REHACARE China
Suzhou, China
www.rehacare-c.com


21-23 August
Medical Fair China
Suzhou, China
www.medicalfair.cn


3-5 September
Thailand Lab International
BITEC, Bangkok, Thailand
www.thailandlab.com


3-5 September
Bio Ap International
BITEC, Bangkok
www.bioapinter.com


9-12 September
China Dental Show
National Exhibition and Convention Center (Shanghai)
www.chinadentalshow.com


10-11 September
Hospital Management Asia
Shangri-La Kuala Lumpur, Malaysia
www.hospitalmanagementasia.com


10-12 September
Medical Fair Thailand
BITEC, Bangkok
www.medicalfair-thailand.com


10-12 September
GITEX Digi Health & Biotech Thailand
BITEC, Bangkok
www.www.gitexdigihealth.com


11-13 September
Bio Asia Pacific
BITEC, Bangkok
www.bioasiapacific.com


16-18 September
OSH India
Hall-6, Bombay Exhibition Centre, Goregaon (E)
www.oshindia.com


24-26 September
Medtec China
Shanghai, China
www.en.medtecchina.com


7-9 October
Malaysia Pharma and Healthcare Expo
Kuala Lumpur, Malaysia
www.mphcexpo.com


9-11 October
Medical Japan Tokyo
Makuhari Messe, Japan
www.medical-jpn.jp


17-19 October
Health Asia
BITEC, Bangkok
www.health-asia.com


17-19 October
Health Asia
BITEC, Bangkok
www.health-asia.com


29-30 October
United Medical Expo
Astana, Kazakhstan
www.umtexpo.com


7-8 November
Eldercare Exhibition and Conference Asia (ELDEX Asia)
Suntex Singapore Exhibition and Convention Centre
www.eldexasia.com


10-12 November
Saudi International Pharma Expo
Riyadh International Convention and Exhibition Center
www.saudipharmaexpo.com


10-12 November
Saudi International MedLab Expo
Riyadh International Convention and Exhibition Center
www.saudimedlabexpo.com


27-29 November
International Wellness Expo (IWE 2025)
METIC, Malaysia
www.internationalwellnessexpo.com


27-29 November
Vietnam Medi-Pharm
Friendship Cultural Palace , Hanoi
www.vietnammedipharm.vn


2026 Events


9-12 Febuary
Arab Health
Dubai World Trade Centre
www.arabhealthonline.com


15-17 April
Lab Indonesia
Jakarta Convention Center, Jakarta, Indonesia
www.lab-indo.com


28-30 April
SEACare
MITEC, KL
wwww.ea-healthcare.com


6-7 May
HealthTechX Asia
Sands Expo & Convention Centre, Singapore
www.healthtechx-asia.com


4-6 June
International Health Industry Expo
China
www.ihe-china.com


16-18 June
CPhI China
SNIEC, Shanghai, China
www.cphi.com


25-27 June
Medical Taiwan
Taipei Nangang Exhibition Center, Taipei, Taiwan
www.medicaltaiwan.com.tw


9-11 September
Medical Fair Asia
Marina Bay Sands, Singapore
www.medicalfair-asia.com


9-11 September
Medical Manufacturing Asia
Marina Bay Sands, Singapore
www.medmanufacturing-asia.com


1-2 October
GITEX Vietnam
Hanoi
www.gitexasia.com