Mouth bacteria linked to risk of stroke
In the single hospital study, researchers at the National Cerebral and Cardiovascular Center in Osaka, Japan, observed stroke that among the patients who experienced intracerebral hemorrhage (ICH), 26 percent were found to have a specific bacterium in their saliva, cnm-positive S. mutans. Among patients with other types of stroke, only 6 percent tested positive for the bacterium.
Strokes are characterized as either ischemic strokes, which involve a blockage of one or more blood vessels supplying the brain, or hemorrhagic strokes, in which blood vessels in the brain rupture, causing bleeding.
The researchers also evaluated MRIs of study subjects for the presence of cerebral microbleeds (CMB), small brain hemorrhages which may cause dementia and also often underlie ICH. They found that the number of CMBs was significantly higher in subjects with cnm-positive S. mutans than in those without.
The authors hypothesize that the S. mutans bacteria may bind to blood vessels weakened by age and high blood pressure, causing arterial ruptures in the brain, leading to small or large hemorrhages.
“This study shows that oral health is important for brain health. People need to take care of their teeth because it is good for their brain and their heart as well as their teeth,” said researcher Robert P. Friedland. “The study and related work in our labs have shown that oral bacteria are involved in several kinds of stroke, including brain hemorrhages and strokes that lead to dementia.”
The cnm-negative S. mutans bacteria is found in approximately 10 percent of the general population, Friedland says, and is known to cause dental cavities (tooth decay). Friedland also is researching the role of oral bacteria in other diseases affecting the brain.
“We are investigating the role of oral and gut bacteria in the initiation of pathology in the neurodegenerative disorders Alzheimer’s and Parkinson’s with collaborators in the United Kingdom and Japan.”
Robert P. Friedland, M.D., the Mason C. and Mary D. Rudd Endowed Chair and Professor in Neurology at the University of Louisville School of Medicine, was a co-author of the study, published online this month in Scientific Reports, a journal of the Nature Publishing Group.
