Study suggests new strategy to treat cancer

A new study by Stony Brook University researchers suggests that instead of targeting invasive cells instead of dividing cells is a more effective strategy to treat cancer.

Researchers found that cells in a roundworm nematode can’t divide and invade at the same time. Only when roundworm cells stop dividing can they become invasive. When cells become invasive, it is the most lethal to a host, as they are the cells that escape tumor tissue to travel and form new tumors.

“Our finding changes how we think about cancer to some level.  While it will remain important to target dividing cells — as cancer is a disease of uncontrolled cell division — we need to figure out how to target non-dividing cells too since they are the invasive ones.” said lead author David Q. Matus, PhD, an Assistant Professor in the Department of Biochemistry & Cell Biology at Stony Brook University.

The team used cells from the worm’s developing uterus called anchor cells to illustrate the division/invasion process. The anchor cells have to invade through a cellular tissue membrane to contact the cells that become the worm’s egg-laying apparatus. Cancer cells operate in a similar manner when leaving one tissue to form another.

Dr. Matus explained that continued research with anchor cells and ongoing genetic analyses of them may further reveal just why they cannot divide and invade at the same time. The research could form the basis of an approach to testing cancer cells and the invasive process.

The paper titled “Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression,” is published in the journal Developmental Cell.

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