Infection-fighting bandage helps treat serious burns
Swiss researches developed a bandage an infection-fighting bandage for patients with serious burns. The bandage speeds up the scarring process for burns to lessen the chances that the wounds will be exposed to bacteria.
An article describing the new bandage, which was developed in part at Ecole Polytechnique Fédérale de Lausanne (EPFL), has just been published in Scientific Reports.
The technology is based on a biodegradable bandage made of animal collagen and ‘progenitor’ cells that can multiply quickly. First developed by the Centre Hospitalier Universitaire Vaudois (CHUV) in 2005, these bandages hastened the healing process but did nothing to protect against microbes. The researchers have now demonstrated that by combining these biological bandages with special molecules called dendrimers, it would be possible to not only speed up healing but also to put a stop to infections.
The bandage consists of a strip of gauze made from collagen to which progenitor cells and dendrimers have been added. When the bandage is placed on a bacteria-infected site, some of the dendrimers migrate and destroy the microbes located in the direct vicinity of the bandage. Other dendrimers remain inside the bandage. “Bandages are a favorable environment for bacterial growth,” said Dominique Pioletti, the head of EPFL’s Laboratory of Biomechanical Orthopedics. “So some dendrimers have to remain in the bandage to destroy any intruders.” With his team, the researcher’s task was to find a way to incorporate dendrimers in the biological bandage. He then observed how the bacteria interacted with the new bandage.
For hospital burn specialists, this technology meets an urgent need. “Currently, we have to take enormous precautions with our patients,” said Lee Ann Laurent-Applegate, the head of the Regenerative Therapy Unit at the CHUV. “The bandages, which sometimes cover most parts of the body, need to be changed every day for several months. Yet that does not stop infections. And we cannot prescribe antibiotics to all patients as a preventive measure for fear of making the bacteria more resistant. With the new bandages, rather than treating infections, we will be preventing them. We are nipping the problem in the bud.”
The new bandage will be tested in Zurich before they can be used in clinics.
Category: Features, Technology & Devices
